Pregnant mothers should beware of 6 factors that may lead to repeated miscarriage

　　Miscarriage is a heavy blow to pregnant mothers. clinical Surveys show that about 15% of pregnant women have experienced miscarriage, and 2% have experienced miscarriage. female I had two miscarriages in a row. Spontaneous miscarriage occurring 2 or more times in a row is called recurrent miscarriage. Sixth Affiliated to Sun Yat-sen University Hospital Associate Professor Xu Linan of the Department of Obstetrics and Gynecology pointed out that in spontaneous abortion,“ embryonic arrest ”It is a common cause in which the development of embryos in early pregnancy stops for some reason. B-ultrasound examination shows fetal bud in the gestational sac or fetus The shape is irregular, there is no fetal heartbeat, or the gestational sac is withered.

　　There are six common causes of recurrent miscarriage

　　1. Genetic factors

　　Mainly refers to abnormalities in the number or structure of chromosomes, which is the most common cause of sporadic early pregnancy loss. About 50% of sporadic pregnancy losses are attributed to this. A pregnant woman's risk of miscarriage increases with the number of previous miscarriages and the age of the mother. About 3% to 5% of couples with recurrent miscarriage have a major chromosomal rearrangement, compared with about 0.7% of the general population. The most common are balanced translocations and inversions. One or both spouses may have heterozygous or balanced combinations of lethal genes that have no effect on themselves but can cause pregnancy loss when inherited by the embryo in a homozygous or unbalanced state.

　　2. Anatomical factors

　　Abnormal uterine anatomy can lead to about 15% to 20% of pregnancy losses. Common uterine anatomical abnormalities mainly include septal uterus, endometrial polyps, submucosal Uterine fibroids , intrauterine adhesions, cervical insufficiency, etc. Among them, the septal uterus is the uterine abnormality with the worst reproductive outcome and is also the most common uterine abnormality associated with recurrent miscarriage.

　　3. Infectious factors

　　During pregnancy, either systemic infection or local infection of the genitourinary system may lead to pregnancy loss. When excluding the causes of recurrent miscarriage, it is very necessary to check for chlamydia, mycoplasma and secretions in the genital tract.

　　4. Endocrine factors

　　Common endocrine abnormalities related to recurrent miscarriage mainly include luteal insufficiency, thyroid dysfunction, hyperprolactinemia, insulin resistance, hyperandrogenism, etc. For patients who are overweight, thin, and have irregular menstruation, special attention should be paid to screening for related endocrine abnormalities.

　　5. Thrombophilia

　　Refers to a class of drugs that can increase thromboembolic disease Risky diseases, due to special changes in the blood system during pregnancy, lead to a hypercoagulable state, leading to an increased possibility of thrombosis, appearing in the tiny blood vessels of the placenta, which may lead to embryonic termination, gestational hypertension, placental abruption , fetal growth restriction and other conditions. Thrombophilia is mainly divided into two categories: hereditary and acquired. The most common of these is antiphospholipid antibody syndrome.

　　6. Immune factors

　　The human immune system is like its own defense system. The immune system will automatically eliminate foreign invaders. Half of the embryos are derived from the father and will be rejected by the immune system. However, in a normal immune system, there is an immune tolerance mechanism that allows the embryo to grow healthily in the mother's body. If the immune system is hyperactive and its ability to reject foreign substances is increased, the embryo will be rejected, leading to spontaneous abortion. Abnormal increases in thyroid antibodies, anti-nuclear antibodies, anti-sperm antibodies, anti-ovarian antibodies, anti-endometrial antibodies, NK cells, B cells, etc. all mean that the body's immune system may be hyperactive.

　　How to avoid miscarriage during pregnancy

　　1. Moderate sexual life

　　Control the frequency of sexual life in a timely manner. If a pregnant mother has frequent sexual intercourse during pregnancy, especially in the early and late stages of pregnancy, miscarriage may occur due to unstable fetal development.

　　2. Avoid overexertion

　　Experts point out that to prevent miscarriage during pregnancy, you should also pay attention to rest in time. Under normal circumstances, if pregnant mothers do not pay attention to rest after pregnancy, such as staying up all night or staying up late at this time, it will cause endocrine disorders, which may lead to miscarriage.

　　3. Maintain a stable mood

　　Generally speaking, you should adjust your psychological and mental state in time. If the expectant mother is emotionally excited during pregnancy (causing central nervous system excitement), it may cause uterine contractions, which may lead to miscarriage.

　　4. Drink more fresh milk

　　Pay attention to dietary issues in time. Under normal circumstances, pregnant mothers should drink more milk during pregnancy, so as to avoid osteoporosis and relieve tension.

　　5. High heels should not be worn

　　Generally speaking, high heels should not be worn during pregnancy. If a pregnant mother wears high heels during pregnancy, especially in the early and late stages of pregnancy, it may easily cause miscarriage or premature birth.