Will the positive reference value of Treponema pallidum increase if the immunity is improved

The answer is definitely not. Not only will improving immunity not raise the reference value for Treponema pallidum positivity, but for people who are already infected, strong enough immunity can help inhibit the replication of Treponema pallidum. Many patients during the follow-up period can see a steady decline in non-specific antibody titers after improving their immunity through regular work and rest.

Many people actually confuse the two concepts of "reference value" and "self-test result". The reference value for syphilis testing is the critical value set by the kit when it leaves the factory. For example, the common reference value for antibody testing is <1COI. This value is fixed and will not change with your physical condition and immunity level. The "increased value" that everyone usually talks about actually refers to their own test results, that is, if the antibody titer exceeds the critical value and is judged as positive, it has nothing to do with the reference value itself.

It is true that many people have similar questions: Since antibodies are produced by the immune system, when there are more antibodies when the immunity is strong, won’t the test results be higher? This statement is only relevant in very special scenarios. For example, people who have just been infected with syphilis and are still in the window period. If their immunity is strong, their bodies will produce antibodies faster, and they may be tested positive three to five days earlier than people with weak immunity. There are also people who have immune deficiencies and then For people whose initial syphilis test is falsely negative, after their immunity recovers later, their body can produce enough antibodies and the test will turn from false negative to positive. However, both cases are manifestations of an increase in the accuracy of the test, and it is not at all "increased immunity leading to an increase in the reference value." They are completely different things.

I met a young man who was an Internet operator when I was outpatient in the dermatology department. When he was first diagnosed with syphilis, the non-specific antibody titer was 1:32. After taking benzathine penicillin according to the course of treatment, he listened to my words I changed my habit of staying up late to catch up on projects. I smoked for half an hour every day and ran late at night. I also stopped smoking and drinking. When I checked again three months ago, the titer dropped directly to 1:2, which was more than twice as fast as that of a patient who was diagnosed at the same time and still stayed up late and drank heavily every day. When he first got sick, he had read rumors on the Internet, saying that the better the immunity, the higher the titer. He was too scared to exercise. When he got the results, he still said that he was lucky not to believe those lies.

Of course, don’t treat immunity as a panacea. Once infected, syphilis-specific antibodies are basically positive for life. Even if your immunity is full, the antibodies are difficult to turn negative. However, as long as the non-specific antibody titer drops to a safe range after regular treatment, it will not affect normal life and is not contagious. There is no need to worry about the positive result.

If you are really found to be positive for syphilis, don't think about relying on improving your immunity to survive. Regular plum-repelling treatment is the core. Immunity is at most an auxiliary buff and cannot be used as the main force.